Pregabalin in Severe Burn Injury Pain: How it works-
When burned, the notices of exposed nerve endings become extremely sensitive, which is called primary hyperalgesia.
Due to repeated stimulation (e.g., pressure, heat, friction, etc.) glutamate, norepinephrine, substance-P, etc. are released, and post-burn develops chronic pain.
Pregabalin binds to the voltage-gated calcium channel beta-2-alpha subunit to block the release of glutamate, norepinephrine, substance-P by preventing continuous or repeated stimulation of nociceptive fibers. As a result, post-burn neuralgia does not develop.
So, Pregabalin acts as one of the most effective weapons to cure post-burn neuropathic pain.